WebSep 6, 2024 · The solution has a pH of 3.0 to 4.5 and contains 0.14 mEq of sodium per mL. The product does not contain preservatives. CLINICAL PHARMACOLOGY Mechanism of Action Mitoxantrone, a DNA-reactive agent that intercalates into deoxyribonucleic acid (DNA) through hydrogen bonding, causes crosslinks and strand breaks. WebSep 6, 2024 · For the approved indications, the clinical data do not suggest that the effectiveness of cisplatin based chemotherapy regimens or radiation therapy is altered by Amifostine for Injection. There are at present only limited data on the effects of amifostine on the efficacy of chemotherapy or radiotherapy in other settings.
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WebSep 3, 2024 · Intravenous infusions should be made slowly over a period of not less than 15 minutes, 30 minutes before beginning cancer chemotherapy and repeated every 2 hours for two doses, then every 3 hours for three doses. The initial two doses should be 2 mg/kg if highly emetogenic drugs such as cisplatin or dacarbazine are used alone or in … WebCisplatin for injection has been administered at 75 mg/m. 2 . to 100 mg/m. intravenously per cycle once every 3 to 4 weeks on Day 1. Other doses and combination regimens have been used. 2.4 Advanced Bladder Cancer . Cisplatin for injection has been administered at 50 mg/m. 2 . to 70 mg/m. intravenously per cycle once every 3 to 4 weeks. horaire bus gigean sete
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WebMay 22, 2024 · GlobalRPH has a medcalc for every major clinical specialty including: Cardiology, Critical Care, Dermatology, Endocrinology, Gastroenterology and Hepatology, Geriatrics, Hematology, Infectious Disease, Neurology, Nephrology, Nutrition (TPN, BMR calculators, Fiber), Oncology, Pain Management, Pharmacokinetics, Psychiatry, … WebCisplatin is a platinum-based agent whose nephrotoxicity is thought related to the chloride in the cis position. Cisplatin gains entry into tubular cells via uptake by the OCT-2 … WebSep 6, 2024 · Treatment is repeated every 3 weeks or after recovery from hematologic toxicity (Platelets ≥100,000/µL, WBC ≥4,000/µL). In order to prevent bladder toxicity, IFEX should be given with extensive hydration consisting of at least 2 … look up someone by ss number