WebDec 4, 2024 · (F) Radiation (2 Gy) reduced the mRNA levels of CTGF and AREG in HA cells and increased them in U251 cells. ( G ) YAP depletion reduced proliferation of U251 (left) and SNB19 (right) cells. ( H and I ) YAP depletion reduced the cytotoxic effect of radiation (10 Gy) on U251 and SNB19 cells as indicated by cell viability ( H ) and colony ... Webof an AREG-promoter fragment (Fig. 2d), comparable to that observed for the promoter of CTGF, a known YAP target gene9,14. Given the identification of AREG as a transcriptional target of YAP, we undertook a series of experiments to test the functional consequences of this interaction. We first tested whether neutralizing antibodies against AREG

Differential radiation response between normal astrocytes and …

WebConnective Tissue Growth Factor (CTGF), also called CCN2, is a member of the CCN family. CTGF is a secreted protein produced by umbilical veins and vascular endothelial … WebResults showed that overexpression of Mst1 inhibited cell proliferation, induced apoptosis of HepG2 cells, promoted YAP (Ser127) phosphorylation, and downregulated the mRNA … der of csc

Amphiregulin - ScienceDirect

WebNov 22, 2009 · Connective tissue growth factor (CTGF) has been recently identified as a transcriptional target of YAP together with the transcription factor TEAD, and they … WebJun 16, 2024 · Target genes of the YAP/TAZ-TEAD complex are genes such as CYR61, CTGF, AREG, VIM [13, 17,18,19]. ... Potter RL, Grotendorst GR (1991) Connective tissue growth factor: a cysteine-rich mitogen secreted by human vascular endothelial cells is related to the SRC-induced immediate early gene product CEF-10. J Cell Biol … Webin HepG2 cells, and reduced the protein levels of Connective Tissue Growth Factor (CTGF), Amphiregulin (AREG), and Survivin, thus inhibiting the proliferation of HepG2 cells and promoting apoptosis [15]. Recent studies [16-18] have shown that abnormalities in the Hippo pathway were closely related to chrstsstvncntrgmdctr