WebMar 11, 2014 · These data suggested that inhibiting cytohesins or ARNO as cytoplasmic activators of EGFR and IGF-I in colorectal cancer resulted in anti-proliferation, reduced invasion, decreased migration, and suppressed growth in vivo and in vitro. Therefore, cytohesins or ARNO may be a potential therapy target for some colorectal cancer. … WebCytohesin-1 is a guanine nucleotide exchange factor for the GTPase ARF as well a regulator of cell adhesion. When injected into athymic mice, the transformed Rat-3 cell …
Recombinant Anti-Cytohesin 1 antibody [EPR10050] (ab154847)
WebJun 6, 2000 · Cytohesin-1 comprises an N-terminal coiled-coil domain, which may aid in oligomerization, a central Sec7 domain and a C-terminal module including the pleckstrin homology (PH) domain and a polybasic region. Cytohesin-1 specifically binds to the intracellular domain of the β-2 integrin chain and has been implicated in the functional … WebFeb 23, 2024 · Initially, CYTH1 was identified in a protein-protein interaction screen and found to interact specifically with the cytoplasmic part of the integrin β2 chain of LFA-1 … eartha kitt santa baby listen
S100A6, Calumenin and Cytohesin 2 as Biomarkers for …
WebCytohesin proteins are ubiquitous and have been implicated in several functions including cell spreading and adhesion, chemotaxis, protein trafficking, and cytoskeletal … WebCytohesin-2 is enriched in the perisynapse on the postsynaptic membrane of dorsal horn neurons and forms a protein complex with mGluR5 in the spinal cord. Central nervous system-specific cytohesin-2 conditional knockout mice exhibited reduced mechanical allodynia in inflammatory and neuropathic pain models. WebCytohesin 1 Antibody (MA1-060) in ICC/IF Immunofluorescence analysis of Cytohesin 1 was done on 70% confluent log phase HeLa cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 10 minutes, and blocked with 1% BSA for 1 hour at room temperature. eartha kitt played catwoman