Cytosolic dna-sensing pathway是什么
WebDec 20, 2012 · To determine whether cGAS is important in the DNA sensing pathway in human cells, we established a THP1 cell line stably expressing a shRNA targeting h-cGAS (fig. S4D). The knockdown of h-cGAS strongly inhibited IFN-β induction by HT-DNA transfection or infection by vaccinia virus, another DNA virus, but not by Sendai virus (fig. … WebApr 30, 2024 · Sensing invasive cytosolic DNA is an integral component of innate immunity. cGAS was identified in 2013 as the major cytosolic DNA sensor that binds dsDNA to catalyze the synthesis of a special ...
Cytosolic dna-sensing pathway是什么
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WebJul 13, 2024 · Once activated by cytosolic DNA signalling, ... Green R, Gale M, Jr., James RC, et al. Human DNA-PK activates a STING-independent DNA sensing pathway. Sci Immunol. 2024;5:eaba4219. WebFeb 1, 2024 · The cGAS–STING Pathway Links Nucleic Acid Sensing to Immune Response. It has been long known that DNA can trigger immune responses, even before DNA was recognized as the genetic blueprint [1].The response to pathogenic DNA is the basis for the evolution of restriction modification systems in bacteria, where restriction …
WebBiological pathway information for Cytosolic DNA-sensing pathway from WikiPathways. WebDec 30, 2024 · Recent evidence has indicated that cytosolic DNA and abnormal activation of the cytosolic DNA sensing adaptor STING (stimulator of interferon genes) play a critical role in vascular …
WebMay 23, 2013 · Although there is also a suggestion that DNA sensing might additionally occur in the nucleus (Kerur et al., 2011; Li et al., 2012), efforts have focused on identifying the pathways that mediate the sensing of DNA in the cell cytosol and link it to inflammation (Figure 4). Download : Download high-res image (595KB) WebNov 30, 2024 · Based on the transcriptome database, cytosolic DNA sensing pathways are widely expressed in the hematopoietic system, and components of these pathways may be expressed at even higher levels in hematopoietic stem and progenitor cells (HSPCs) than in their certain progeny immune cells. Recent studies have described a previously …
WebMay 5, 2013 · Cytosolic signaling pathways activated by DNA have been uncovered, new DNA receptors proposed, and we now know that innate DNA recognition is closely …
WebNov 30, 2024 · Cytosolic DNA sensing is a fundamental mechanism by which organisms handle various stresses, including infection and genotoxicity. The hematopoietic system is sensitive to stresses, and hematopoietic changes are often rapid and the first response to stresses. Based on the transcriptome database, cytosolic DNA sensing pathways are … ear bone hearing aidWebApr 30, 2024 · DNA is a pathogen-associated molecular pattern when delivered to the host cytoplasm by viral or microbial infection, and a danger-associated molecular pattern … ear bone known as the stirrupWebKEGG PATHWAY: Cytosolic DNA-sensing pathway ear bone piercingWebActivation of cytosolic DNA sensing pathways impacts on autophagy and tumor antigens (Ags) cross-presentation in DCs. Type-I IFNs production by DCs actually represents the … ear bone anatomyWebJul 29, 2024 · Cytosolic DNA sensing by the cyclic GMP–AMP synthase (cGAS)–stimulator of interferon genes (STING) pathway is implicated in a variety of biological processes. css3 grid布局css3h5WebApr 30, 2024 · The cGAS–STING signaling pathway senses cytosolic DNA derived from either viral/bacterial infection or self-DNA. DNA is a pathogen-associated molecular pattern when delivered to the host cytoplasm by viral or microbial infection, and a danger-associated molecular pattern when leaked into the cytoplasm from damaged mitochondria or … css 3 grids