WebThe present invention provides thienopyridine derivatives, which are useful as anti-inflammatory drugs, particularly as remedies for arthritis; processes for producing them, and pharmaceutical compositions containing them. The thienopyridine derivatives are represented by the formula (I), wherein G is a halogen atom, hydroxyl group, an optionally … WebThe present invention provides thienopyridine derivatives, which are useful as anti-inflammatory drugs, particularly as remedies for arthritis; processes for producing them, and pharmaceutical compositions containing them. The thienopyridine derivatives are represented by the formula (I):wherein G is a halogen atom, hydroxyl group, an optionally …
EP0292051A2 - Thienopyridine derivatives - Google Patents
Thienopyridines are a class of selective, irreversible ADP receptor/P2Y12 inhibitors used for their anti-platelet activity. They have a significant role in the management of cardiovascular disease. See more They are used in the management of peripheral artery disease, as well as the prevention of coronary stent thrombosis and strokes. See more Drugs in this class include: clopidogrel (Plavix), prasugrel (Effient), and ticlopidine (Ticlid). Tinoridine was … See more Ticagrelor (Brilinta) is often listed with thienopyridine inhibitors and has similar indications for use but is not a thienopyridine. It is a … See more Web30 Nov 2024 · The scientists studied the reactions of thienopyridine derivatives with substances from six different groups: alkynes, aldehydes, alcohols, and other organic compounds. splitsort
Quantum mechanics and 3D-QSAR studies on thienopyridine …
Web1 Nov 1997 · Clopidogrel is a thienopyridine that irreversibly inhibits platelet aggregation by selectively binding to adenylate cyclase-coupled ADP receptors on the platelet surface. In animal models, clopidogrel reduced the formation of both arterial and venous thrombi. After oral administration, clopidogrel is rapidly absorbed and undergoes metabolic ... WebThe thienopyridine class of antiplatelet agents has been developed to inhibit blood clots in coronary artery disease, peripheral vascular disease, and cerebrovascular disease. They are prescribed in patients who either do not tolerate aspirin or … Web1 Jan 2003 · Clopidogrel appears to offer several advantages over ticlopidine: a more rapid onset of action and a lower incidence of neutropenia and thrombotic thromBocytopenic purpura. Summary The thienopyridines, ticlopidine and clopidogrel, are antiplatelet drugs. They are prodrugs and are metabolised in the liver to active metabolites that are … splits ops